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What is
allogeneic GM-CSF-based myeloma cell vaccine
?Pronunciation: /allogeneic* gm* csf* beɪst myeloma* sɛl ˌvækˈsin/
allogeneic GM-CSF-based myeloma cell vaccine
Definition
An allogeneic tumor cell vaccine containing myeloma cancer cells transfected with the granulocyte macrophage-colony-stimulating factor (GM-CSF) gene with potential antineoplastic activity. Upon vaccination, allogeneic GM-CSF-based myeloma cellular vaccine secretes GM-CSF, which may potentiate a tumor-specific cytotoxic T-lymphocyte (CTL) response against myeloma cancer cell-associated antigens.