Definition

A preparation of genetically modified allogeneic gamma delta T lymphocytes, with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic gene-modified gamma delta T cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. The genetic modification of the allogeneic gene-modified gamma delta T cells may confer resistance to alkylating chemotherapeutic agents including temozolomide and allow the use of the gamma delta T cells as an adjunct to these agents.