Definition

A suicidal inhibitor of aldehyde dehydrogenases 1 (ALDH1) and 3 (ALDH3), with potential antineoplastic activity. Upon administration, ALDH1/3 inhibitor ABD-3001 targets, binds to and irreversibly inhibits the activity of ALDH1 and ALDH3. This results in the accumulation of reactive aldehydes in tumor cells, which interferes with oncogenic signaling pathways and tumor cell proliferation. In addition, the inhibition of ALDH1 and ALDH3 disrupts glutathione redox balance in tumor cells, leading to oxidative stress which may further promote tumor cell death.