Single Biggest Cancer Dictionary in the World
What is
Akt inhibitor LY2780301
?Pronunciation: /akt* ˌɪnˈhɪbətər laɪ tu ˈmɪljən, ˈsɛvən ˈhənərd ənd ˈeɪti ˈθaʊzənd, θri ˈhənərd ənd wən/
Akt inhibitor LY2780301
Definition
An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway, thereby leading to inhibition of cell proliferation and the induction of apoptosis in tumor cells. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.