Single Biggest Cancer Dictionary in the World
What is agonistic anti-OX40 monoclonal antibody MEDI6469?
Pronunciation: /agonistic* ˈænˌti ɑks ˈfɔrti ˌmɑnəˈkloʊnəl ˈæntɪˌbɑdi ˈmɛdi sɪks ˈθaʊzənd, fɔr ˈhənərd ənd sixty-nine*/
agonistic anti-OX40 monoclonal antibody MEDI6469
Definition
An agonistic monoclonal antibody against the co-stimulatory receptor OX40 (CD134), with potential immunostimulatory and antineoplastic activities. Upon intravenous administration, anti-OX40 monoclonal antibody MEDI6469 selectively binds to and activates OX40. OX40 activation induces proliferation of effector T lymphocytes. In the presence of tumor-associated antigens (TAAs), this may promote an immune response against the TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on T lymphocytes and provides a co-stimulatory signal for the proliferation and survival of activated T cells.