Single Biggest Cancer Dictionary in the World
What is adenovirus serotype 26-expressing HPV16 vaccine JNJ-63682918?
Pronunciation: /əˈdɛnəˌvaɪrəs serotype* twenty-six* ɪkˈsprɛsɪŋ hpv* ˈsɪkˈstin ˌvækˈsin jnj* sixty-three* ˈmɪljən, sɪks ˈhənərd ənd eighty-two* ˈθaʊzənd, naɪn ˈhənərd ənd ˈeɪˈtin/
adenovirus serotype 26-expressing HPV16 vaccine JNJ-63682918
Definition
A prime cancer vaccine comprised of a genetically engineered, replication-deficient adenovirus serotype 26 (Ad26) encoding the oncogenic human papillomavirus 16 (HPV16), with potential immunostimulating and antineoplastic activities. Upon intramuscular administration of Ad26-expressing HPV16 vaccine JNJ-63682918, the adenovirus infects and expresses HPV16. The expressed proteins stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing HPV16 antigens, thereby inducing tumor cell lysis. HPV16 infection plays a key role in the development of a variety of cancers.