Single Biggest Cancer Dictionary in the World
What is adenosine A2A receptor antagonist PBF-509?
Pronunciation: /əˈdɛnəˌsin ə tu ə riˈsɛptər ænˈtægənəst pbf* faɪv ˈhənərd ənd naɪn/
adenosine A2A receptor antagonist PBF-509
Definition
An orally bioavailable adenosine A2A receptor (A2AR) antagonist, with potential antineoplastic activity. Upon administration, A2AR antagonist PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. Adenosine is often produced in excess by cancer cells.