Definition

An inhibitor of the glycosyltransferase N-Acetylglucosaminyltransferase V (GnT-V), with potential antineoplastic activity. Upon administration, GnT-V inhibitor PhOx430 targets, binds to and inhibits the activity of GnT-V, a glycosylation enzyme that synthesizes the beta1, 6-GlcNAc branch in N-glycans. This inhibits the glycosylation of tumor cells and downregulates cell surface receptors implicated in tumor cell growth and metastasis. GnT-V and its product N-glycans, upregulated in various types of cancer cells, are associated with cancer proliferation and metastasis.