Single Biggest Cancer Dictionary in the World
What is ABT-751?
Pronunciation: /ˈeɪˈbiˈti ˈsɛvən ˈhənərd ənd fifty-one*/
ABT-751
Definition
An orally bioavailable antimitotic sulfonamide. ABT-751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect.