Single Biggest Cancer Dictionary in the World

What is ABT-751?

Pronunciation: /ˈeɪˈbiˈti ˈsɛvən ˈhənərd ənd fifty-one*/

ABT-751

Definition

An orally bioavailable antimitotic sulfonamide. ABT-751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect.