Definition

A Toll-like receptor (TLR) 7 agonist with potential immunostimulating and antineoplastic activities. Upon administration, TLR7 agonist SHR2150 targets, binds to and activates TLR7. This may trigger, in addition to other possible responses, the activation of dendritic cells (DCs), macrophages and B cells, and activate cluster of differentiation (CD) 8+ T cells. This may induce anti-tumor immune responses. TLR7 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.