Single Biggest Cancer Dictionary in the World

What is survivin Sur1M2 peptide vaccine?

Pronunciation: /survivin* sər wən ɛm tu ˈpɛpˌtaɪd ˌvækˈsin/

survivin Sur1M2 peptide vaccine

Definition

A modified recombinant nonapeptide (LMLGEFLKL) derived from the anti-apoptosis protein survivin with potential immunopotentiating and antineoplastic activities. Upon administration, survivin Sur1M2 peptide vaccine may elicit humoral and cellular immune responses against survivin-expressing cancers, resulting in decreased tumor cell proliferation and tumor cell death. The survivin protein inhibits caspase activation and apoptosis; it is undetectable in normal adult tissues but is expressed by several human cancers including lung, colon, breast, pancreas, and prostate cancer as well as hematopoietic malignancies and skin cancers.