Single Biggest Cancer Dictionary in the World
What is PPI-2458?
Pronunciation: /ppi* tu ˈθaʊzənd, fɔr ˈhənərd ənd fifty-eight*/
PPI-2458
Definition
A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class.