Definition

A nanoparticle-based formulation consisting of an antigenic acetylcholine receptor (AChR) peptide pool dispersed within a negatively charged polymer matrix of poly(dl-lactide-co-glycolide) (PLGA) particles, with potential immunomodulatory activity. Upon administration, nanoparticle encapsulated AChR epitopes CNP-106 binds to inflammatory cells and delivers multiple AChR epitopes, which initiates tolerogenic immune reprogramming. This may induce and promote antigen-specific tolerance against AChR, which may prevent neuromuscular junction damage and dysfunction that results from autoimmunity targeting AChR.