Definition

A dietary supplement composed of a phosphobioflavonic complex containing two naturally occurring dietary ingredients: the phospholipid N-oleyl-phosphatidylethanolamine (NOPE), which consists of the fatty acid amide oleoyl ethanolamine (OEA) bound to phosphatidylethanolamine (PE), and the flavonol epigallocatechin gallate (EGCG), which is derived from standardized green tea extract, with potential anorexic activity. Upon oral administration of the NOPE/EGCG supplement, NOPE is hydrolyzed into the N-acylethanolamine N-oleyl-ethanolamide (NOE) and phosphatidic acid. NOE inhibits anandamide, thereby preventing the increase in appetite and promotes the activation of several intestinal receptors, which signal the brain center to reduce food intake. EGCG inhibits enzymes that contribute to the degradation of catecholamines, stimulates lipolysis, and promotes weight loss. NOPE and EGCG may work together to provide satiety, improve adherence to a diet, improve performance on impulsivity, and shift fat and sweet preference. This may reduce weight gain and may increase weight loss.