Definition

An orally bioavailable molecular glue degrader (MGD) composed of an E3 ubiquitin ligase-binding moiety that is conjugated, via a linker, to an as of yet undisclosed target protein, with potential antineoplastic activity. Upon oral administration, MGD GLB-001 targets and binds to the undisclosed target protein on tumor cells and to E3 ubiquitin ligase, thereby creating a ternary complex. This induces E3 ligase ubiquitination and proteasome-mediated degradation of the undisclosed target. This may result in an inhibition of tumor cell growth in which the target protein is upregulated or dysregulated.