Single Biggest Cancer Dictionary in the World
What is hTERT I540/R572Y/D988Y multipeptide vaccine?
Pronunciation: /htert* aɪ faɪv ˈhənərd ənd ˈfɔrti ɑr faɪv ˈhənərd ənd seventy-two* waɪ di naɪn ˈhənərd ənd eighty-eight* waɪ multipeptide* ˌvækˈsin/
hTERT I540/R572Y/D988Y multipeptide vaccine
Definition
A peptide vaccine consisting of multiple epitopes derived from the human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, with potential immunostimulating and antineoplastic activities. hTERT I540/R572Y/D988Y multipeptide vaccine contains strongly antigenic peptide epitopes I540 (9-mer), R572Y (9-mer) and D988Y (10-mer). Vaccination with this agent may elicit a cytotoxic T cell (CTL) response against telomerase-expressing tumor cells. Directly linked to tumorigenesis, telomerase is expressed in the majority of human cancer cells but is infrequently expressed in normal cells.