Definition

A radioconjugate composed of YJH08, a synthetic glucocorticoid receptor (GR) agonist, labeled with the positron-emitting isotope carbon C 11, with potential use in imaging via positron emission tomography (PET). Upon intravenous administration of carbon C 11 YJH08, the YJH08 moiety targets and binds to GR on tumor cells. Upon PET imaging, this radioligand may allow for the assessment of GR-expressing tumor cells. This also allows assessment of YJH08’s pharmacokinetic profile and affinity of GR-positive tumor cells. The GR, a member of the nuclear receptor superfamily of ligand-dependent transcription factors, is overexpressed in certain tumor types and may be associated with tumor cell proliferation and treatment resistance.