Definition

A topical cream containing the alkaloid caffeine in a lipoderm base, with potential anti-inflammatory, anti-fibrotic, protective and antioxidant activities. Upon topical application of the caffeine-based cream to the affected area(s), the caffeine inhibits phosphodiesterase (PDE) activity, thereby stimulating the degradation of fats during lipolysis. Caffeine also reduces the levels of certain pro-inflammatory cytokines, such as the profibrotic cytokine transforming growth factor beta (TGFb,) and matrix metalloproteinases (MMPs), thereby preventing inflammation and protecting against collagen degradation. In addition, caffeine protects cells from oxidative stress. This may help protect skin, reduce skin-related complications and improve skin appearance.