Definition

A T-cell redirecting agent and bispecific antibody targeting an as of yet undisclosed tumor-associated antigen (TAA) expressed on tumor cells and the CD3 receptor complex expressed on T cells, with potential immunomodulating and antineoplastic activities. Upon administration, bispecific antibody JNJ-70218902 binds to both CD3 on T cells and a TAA expressed on tumor cells. The resulting cross-linkage activates and redirects T cells to the TAA-expressing tumor cells. This results in T-cell-mediated lysis of tumor cells.