Definition

An agent that targets the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and redirects T-cells to PSMA-expressing tumor cells, with potential antineoplastic activity. Although the mechanism of action has not been elucidated, upon administration, PSMA-targeting T-cell redirecting agent JNJ-80038114 targets PSMA found on PSMA-expressing tumor cells, and redirects T cells to the PSMA-expressing tumor cells. This may result in T-cell-mediated cell death of PSMA-expressing tumor cells. PSMA, a type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors.