Definition

An immunoglobulin G2 (IgG2) monoclonal antibody directed against the receptor activator of nuclear factor kappa beta ligand (RANKL), with antiosteoclast activity. Upon administration, anti-RANKL monoclonal antibody HS-20090 specifically binds to RANKL and blocks the interaction of RANKL with RANK, a receptor located on osteoclast cell surfaces. This results in an inhibition of osteoclast activity, a decrease in bone resorption, and a potential increase in bone mineral density. RANKL, a protein expressed by osteoblastic cells, plays an important role in osteoclastic differentiation and activation.