Definition

An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the cell surface adhesion molecule and tumor-associated antigen (TAA) nectin-4 (PVRL4) that is conjugated to the tubulin inhibitor and cytotoxic agent AP052, with potential antineoplastic activity. Upon administration of the anti-nectin-4 ADC ADRX-0706, the anti-nectin-4 antibody targets and binds to nectin-4 expressed on tumor cells. Upon binding and internalization, AP052 targets and binds to tubulin, and inhibits its polymerization. This results in G2/M phase arrest and induces apoptosis in nectin-4-expressing tumor cells. Nectin-4, a TAA belonging to the nectin family, is overexpressed in a variety of cancers, but has a restricted distribution in normal tissue. It is associated with poor disease prognosis. ADRX-0706 has a drug-antibody ratio (DAR) of eight.