Definition

A humanized monoclonal antibody directed against human hepatocyte growth factor (HGF), with potential antineoplastic activity. Upon administration, anti-HGF monoclonal antibody YYB101 targets and binds to HGF, preventing the binding of HGF to the HGF receptor c-Met and the activation of the c-Met signaling pathway. This may result in cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis.