Definition

A monoclonal antibody directed against the tumor-associated antigen (TAA) CD147 (Basigin; EMMPRIN; extracellular matrix metalloproteinase inducer; OX47; 5A11), with potential antineoplastic activity. Upon administration, anti-CD147 monoclonal antibody DS-1471 targets and binds to CD147, thereby inhibiting the binding of CD147 to its binding molecules and CD147 molecular chaperone functions. This inhibits CD147-mediated stabilization and recycling of various CD147-binding proteins, including CD44, integrins, and monocarboxylate transporter 1 (MCT1), and inhibits downstream signal transduction pathways mediated by these proteins. This may lead to cancer cell death. CD147, a cell-surface glycoprotein of the immunoglobulin G (IgG) superfamily, is overexpressed in certain human tumors and plays an important role in tumor cell proliferation, migration, progression, and metastasis.