Single Biggest Cancer Dictionary in the World
What is allogeneic cytomegalovirus-specific cytotoxic T lymphocytes?
Pronunciation: /allogeneic* ˌsaɪtəˌmɛgəloʊˈvaɪrəs spɪˈsɪfɪk cytotoxic* ti ˈlɪmfəˌsaɪts/
allogeneic cytomegalovirus-specific cytotoxic T lymphocytes
Definition
A population of allogeneic cytotoxic T lymphocytes (CTLs) specifically reactive to the herpes virus cytomegalovirus (CMV) with potential immunomodulating and antiviral activities. Upon immunoprophylactic adoptive cell therapy infusion with allogeneic cytomegalovirus-specific cytotoxic T lymphocytes, these CTLs may help reconstitute CMV-specific CTL responses in CMV-infected immunocompromised hosts after allogeneic hematopoietic stem cell transplant, thereby potentially preventing the occurrence of CMV viral disease or reducing the amount of antiviral drug therapy.