Single Biggest Cancer Dictionary in the World
What is Akt inhibitor GSK2141795?
Pronunciation: /akt* ˌɪnˈhɪbətər gsk* tu ˈmɪljən, wən ˈhənərd ənd forty-one* ˈθaʊzənd, ˈsɛvən ˈhənərd ənd ninety-five*/
Akt inhibitor GSK2141795
Definition
An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.