Single Biggest Cancer Dictionary in the World
What is actinium Ac 225-DOTA-h11B6 JNJ-69086420?
Pronunciation: /actinium* ˈeɪˈsi tu ˈhənərd ənd tˈwɛntiˌfaɪv dota* eɪʧ ˈilɛvən bi sɪks jnj* sixty-nine* ˈmɪljən, eighty-six* ˈθaʊzənd, fɔr ˈhənərd ənd tˈwɛnti/
actinium Ac 225-DOTA-h11B6 JNJ-69086420
Definition
A radioimmunoconjugate containing h11B6, a humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets human kallikrein-2 (hK2), conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), and labeled with the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic activity. Upon administration of actinium Ac 225-DOTA-h11B6 JNJ-69086420, the monoclonal antibody moiety of JNJ-69086420 targets and binds to hK2, thereby delivering a cytotoxic dose of alpha radiation to hK2-expressing tumor cells. hK2 is overexpressed on a variety of cancer cells.