Definition

A drug used to treat adults with non-small cell lung cancer that has spread and has a certain mutation (change) in the KRAS gene. It is used in patients who have already received at least one other systemic therapy. It is also being studied in the treatment of other types of cancer. Sotorasib blocks a protein (KRAS p.G12C) made by the mutated KRAS gene, which may help keep cancer cells from growing and may kill them. It is a type of targeted therapy. Also called Lumakras.