Definition

A combination of symptoms caused by damage to the tiny blood vessels in the kidney that filter waste and extra fluid from the blood and send them to the bladder as urine. Signs and symptoms of nephrotic syndrome include higher-than-normal amounts of protein in the urine and fat and cholesterol in the blood. Swelling, especially in the legs, feet, or ankles, may occur. Nephrotic syndrome may be caused by certain diseases that affect only the kidneys or by infection, immune system disorders (such as lupus), certain genetic disorders, and other diseases or conditions, such as cancer, diabetes, and amyloidosis. It may also be caused by taking certain medicines. Nephrotic syndrome can occur in both children and adults.