Definition

A drug used to treat children aged 2 years and older with a rare genetic condition called neurofibromatosis type 1. It is used in patients who have plexiform neurofibromas that are causing symptoms and cannot be removed by surgery. It is also being studied in the treatment of some types of cancer. Koselugo blocks proteins called MEK1 and MEK2, which may help keep abnormal cells or cancer cells from growing. It is a type of kinase inhibitor. Also called AZD6244, MEK inhibitor AZD6244, and selumetinib sulfate.