Definition

A drug used alone to treat adults with a group of blood disorders called histiocytic neoplasms and with vemurafenib to treat adults with melanoma that has spread or cannot be removed by surgery and has a certain mutation (change) in the BRAF gene. It is also being studied in the treatment of other types of cancer. Cotellic blocks proteins called MEK1 and MEK2, which may help keep tumor cells from growing. It is a type of kinase inhibitor. Also called cobimetinib fumarate.